In 2025, health isn’t just a priority—it’s a movement. Americans are ordering lab tests at record levels, not just when they’re sick, but to optimize performance, track long-term wellness, and catch silent threats before they strike. From tech-savvy Gen Z biohackers to busy parents managing chronic conditions, people are skipping long doctor waits and heading straight to lab portals—one test at a time.

But among the hundreds of available options, a few lab tests have quietly taken center stage. They’re being ordered millions of times, shaping clinical decisions, driving insurance reimbursements, and powering the backend of nearly every wellness app you know.

These aren’t just medical checkboxes—they’re the unsung heroes of preventive care, chronic disease management, and even life-saving diagnosis. And they’re a window into what America is really worried about when it comes to health.

Let’s unpack the five lab tests dominating the charts in 2025—and the numbers behind their rise.

🧪 1. Complete Blood Count (CBC)

No surprises here—CBC remains the king of lab tests. Whether it’s a routine wellness screen or the first diagnostic move when something feels off, the CBC is healthcare’s go-to blood test.

• Percentage of lab orders (2023): 7.03% (Definitive Healthcare, 2024)
• Use cases: Detects infections, anemia, immune disorders, blood cancers
• Fun fact: A single CBC panel can offer up to 15 data points from one vial of blood.

CBC is often the first test ordered in emergency rooms and wellness checkups alike. It’s essential, fast, and highly informative—making it the backbone of preventive medicine.

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💧 2. Comprehensive Metabolic Panel (CMP)

Right behind CBC, the CMP is a powerhouse. It checks the status of kidneys, liver, electrolytes, and blood sugar—all in one panel.

• Lab volume share (2023): 6.51% (Avalon Healthcare Solutions, 2024)
• Key markers: Glucose, calcium, sodium, potassium, BUN, creatinine, liver enzymes
• Why it matters: Reveals silent dysfunction in vital organs

More than a routine screen, a CMP is a window into your metabolic engine—flagging signs of diabetes, dehydration, kidney or liver damage before symptoms ever appear.

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❤️ 3. Lipid Panel

With heart disease still the #1 cause of death in the U.S., the Lipid Panel’s popularity speaks volumes. People aren’t waiting for symptoms—they’re checking their cholesterol early and often.

• Percentage of lab tests: 3.65% (Definitive Healthcare, 2024)
• What’s measured: Total cholesterol, HDL, LDL, triglycerides
• Emerging trend: Gen Z is testing earlier due to family history concerns

Lipid panels are key in cardiovascular risk prediction. They’re also frequently included in employer wellness plans and insurance-covered physicals.

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🧬 4. Hemoglobin A1c (HbA1c)

With 1 in 10 Americans living with diabetes and millions more at risk, it’s no wonder HbA1c continues to surge in demand.

• Lab share: 3.33% of all procedures in 2023 (WebFX, 2024)
• What it shows: Your average blood sugar over the last 3 months
• Why it’s different: Unlike a glucose test, HbA1c doesn’t fluctuate with meals

It’s become the gold standard for diagnosing and monitoring diabetes, often used by individuals ordering their own tests to avoid delays in care.

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🦋 5. Thyroid Stimulating Hormone (TSH)

Fatigue, weight gain, anxiety—thyroid dysfunction mimics so many conditions that TSH testing has exploded in 2025.

• Lab order frequency: 2.63% of all tests in 2023 (CLP Magazine, 2024)
• What it screens for: Hypothyroidism, hyperthyroidism, autoimmune thyroid issues
• Notable rise: Increased among women ages 25–45 due to hormone tracking trends

TSH is a top test in women’s health, fertility evaluations, and long-COVID management.

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📊 What This Says About Healthcare in 2025

• Over 14 billion lab tests are performed annually in the U.S. (Avalon, 2023)
• Labs influence up to 70% of medical decisions (Mayo Clinic Labs, 2025)
• Consumers now order over 30% of tests directly online, bypassing traditional gatekeepers (Grand View Research, 2025)

At Lab Testing API, we’re seeing this shift firsthand. Consumers want control, convenience, and confidentiality—and the most-ordered tests reflect just that.

🧠 Final Thought

The top tests of 2025 tell a powerful story: people are prioritizing prevention, metabolic health, and hormonal balance. They’re not waiting for symptoms—they’re testing proactively, armed with data, and reshaping the future of healthcare from the bottom up.

Want to join the lab testing revolution?
Explore 400+ affordable tests at LabTestingAPI

References

• Avalon Healthcare Solutions. (2023). 2023 Lab Trend Report: Volume and Cost of Clinical Lab Tests Expected to Rise. https://www.avalonhcs.com
• CLP Magazine. (2024). 17 Lab Testing Trends That Will Define 2025. https://clpmag.com
• Definitive Healthcare. (2024). Most Commonly Ordered Lab Tests by Procedure Volume. https://www.definitivehc.com
• Grand View Research. (2025). Clinical Laboratory Tests Market Size and Forecast. https://www.grandviewresearch.com
• Mayo Clinic Labs. (2025). 4 Statistics That Showcase the Broad Impact of Laboratory Medicine. https://news.mayocliniclabs.com
• WebFX. (2024). Medical Laboratory Industry Statistics. https://www.webfx.com